SPONSOR: V Foundation for Cancer Research
THE PROBLEM: Despite intense research, there are still large knowledge gaps in our understanding of cancer in dogs, especially the genetic underpinnings of the disease. We know even less about dogs that develop multiple cancers in their lifetime. Learning more about the genetics of dogs prone to multiple cancers could lead to new genetic testing as well as potential therapies for this population of dogs.
THE PROJECT: The team will use genetic data and advanced computer technology to comb through the DNA of dogs both with and without multiple cancer diagnoses. They will be searching for differences in the genetic sequence between the two populations. Once identified, these regions can serve as a starting point for further research.
POTENTIAL IMPACT: By identifying genetic variations associated with a risk for developing multiple cancers, the results of this study could:
- Further our understanding of why cancer develops in certain dogs
- Lead to the development of genetic tests and risk assessments for cancer
- Influence breeding decisions
- Point to possible treatment targets
- Help with future studies looking at the intersection between genetics and the environment
Study ID
D24CA-704
Study Status
Active
Grant amount awarded
$100,191
Grant recipient
Broad Institute
Study country
United States
Investigator
Katherine Megquier
Study category
Cancer