SUMMARY: Researchers will uncover genes for disease outcomes and antimicrobial resistance in Rhocococcus equi, the agent responsible for serious foal pneumonia.
THE PROBLEM: Rhodococcus equi infections are a significant cause of mortality in young horses. R. equi, commonly found in soil, presents challenges due to its capacity to cause severe disease that is often resistant to treatment. Current gaps in knowledge include understanding how specific genes in the pathogen affect disease outcomes and antimicrobial resistance levels. New information on R. equi’s genetic make-up could help close these gaps and lead to better treatments.
THE PROJECT: This research project aims to uncover the genetic factors influencing the severity of disease and antimicrobial resistance of Rhodococcus equi infections. The study team hypothesizes that genes governing virulence, pathogenicity, and antimicrobial resistance in R. equi contribute to poor foal outcomes. By analyzing the genomes of 300 R. equi isolates, researchers aim to identify key genetic markers associated with disease severity and antimicrobial resistance. Specifically, the team will assess how antimicrobial resistance genes impact treatment efficacy and which pathogen genes correlate with disease severity.
POTENTIAL IMPACT: This research addresses critical gaps in our understanding of R. equi infections,offering insights that could revolutionize treatment protocols and preventive measures in veterinary medicine. By elucidating the genetic underpinnings of R. equi pathogenicity and antimicrobial resistance, this study holds promise for significant advancements in equine healthcare and disease control.
Projected End Date: 2/28/28
Study ID
D25EQ-045
Study Status
Active
Grant amount awarded
$99,511
Grant recipient
Auburn University
Study country
United States
Investigator
Laura Huber, MSc, DVM, PhD