Linking Acute Chronic Diarrhea to Changes in the Gut Microbiome and Disease
Researchers will investigate if acute episodes of diarrhea in dogs have a long-term impact on gut microbes and intestinal health.
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Understanding How Heart Cells Transform from Normal to Abnormal Cells in Mitral Valve Disease
Researchers will look at how lesions or nodules form in dogs with mitral valve disease and use this new information to look for new targeted therapies for this common canine heart disease.
Understanding the Role of Metabolism in Bone Cancer
Researchers will study metabolic irregularities associated with osteosarcoma that may contribute to disease progression, chemotherapy resistance and cancer spread.
Working Toward an Immunotherapy for Osteosarcoma
Researchers will investigate the effectiveness of combining radiation therapy with an immune-stimulating agent to help slow the spread of osteosarcoma, the most common bone tumor in dogs.
Searching for New Analgesic Targets for Chronic Osteoarthritis Pain
Researchers will learn more about what drives pain in dogs with osteoarthritis and use this new information to help identify safer pain relief options for affected animals.
Evaluating an Early Diagnostic Test for Urinary Tract Cancer
Researchers will investigate the validity of a novel diagnostic test for the early detection of urothelial carcinoma, also known as transitional cell carcinoma, the most common urinary tract cancer in dogs.
Ensuring the Safety of Novel Degenerative Myelopathy Therapy
Researchers will conduct a small safety trial evaluating a novel treatment aimed at silencing a genetic mutation associated with degenerative myelopathy, an incurable, progressive disease of the spinal cord.