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Shuttling calcium between cellular compartments is critical to normal muscle function. Abnormal movement of calcium can contribute to muscle degeneration and even failure. Researchers will explore biological mechanisms involved in equine muscle calcium regulation and “tying up,” a complex muscle disorder of horses. Researchers also will study how key equine inhibitory proteins affect the structural dynamics of the muscle calcium pump which helps control intramuscular calcium levels in the body. By discovering how horses regulate muscle calcium levels, researchers hope to identify new therapeutic targets for treating debilitating equine muscle diseases.

Study ID
D16EQ-004
Study Status
Complete
Start Date
04/01/2016
Grant amount awarded
$141,620
Grant recipient
Michigan State University
Study country
United States
Investigator
Stephanie J. Valberg, DVM, PhD
Study category
Musculoskeletal