Understanding Genetic Risk for Developing Calcium Oxalate Urinary Stones

Urinary stones composed of calcium oxalate are a common problem in dogs. They can cause significant bladder irritation and lead to life-threatening urethral obstructions. Researchers discovered two genetic mutations strongly linked to calcium oxalate urinary stone formation in some dog breeds. In this follow-up study, the team will further evaluate these mutations in multiple breeds to confirm the mutations' role in stone formation. Understanding the genetic basis of urinary stone formation is fundamental to developing new diagnostic, therapeutic, and preventive strategies, including genetic testing. A genetic test would help inform breeding decisions and identify at-risk dogs that may benefit from regular stone screening, dietary changes or other medical interventions.