Understanding Genetic Mutations Associated with Drug Variability

Researchers will analyze genetic mutations associated with drug metabolism pathways. Data will be used to develop a novel, drug sensitivity test to determine if a dog is a slow, fast or normal processor of drugs, called the phenotype. Knowing the drug processing phenotype of a dog could help veterinarians make informed and individualized drug treatment decisions for their patients, such as whether to increase or decrease the amount of a drug dosage or when to use an alternative drug. The successful development of this test could lead to increased safety and efficacy of therapeutic drugs for all dogs, improving personalized medicine.