Newfoundland dogs can present with an inherited orthopedic disorder called forelimb anomaly that is characterized by short stature and bowed, thickened front legs. Although early studies supported a simple recessive mode of inheritance, further research showed that disease manifestation is more complex. Recent technological advances have the potential to clarify the inheritance of this disease. In this study, researchers will compare the genomes of affected Newfoundland dogs and of their parents that show no signs of the disorder. Their goal is to identify agenetic variants or regions that may contribute to this condition. If successful, findings will help inform future genetic screening tests for forelimb anomaly in Newfoundland dogs and may provide additional insights into the development of other bone abnormalities in other breeds of dogs, including elbow dysplasia.
Study ID
D21CA-503
Study Status
Complete
Start Date
04/01/2021
Grant amount awarded
$10,000
Grant recipient
Michigan State University
Study country
United States
Investigator
Vilma Yuzbasiyan-Gurkan, PhD
Study category
Musculoskeletal