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Chronic inflammatory enteropathies (CIE) are a group of intestinal disorders characterized by persistent or recurrent gastrointestinal signs. Dogs with CIE often have frequent flare-ups and intestinal inflammation associated with changes in gut bacteria, and the cause of these flare-ups is rarely known. Researchers want to know if synbiotics (a mixture of probiotics and prebiotics) provide a health benefit to dogs with CIE. The team will study how synbiotics influence DNA methylation, a process by which genes promoting inflammation can be turned on and off. Findings from this study will provide a better understanding of how synbiotics work in the dog’s digestive system and if they can regulate gene expression to reduce gastrointestinal inflammation in dogs with CIE.

Study ID
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Grant amount awarded
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Iowa State University Foundation
Study country
United States
Albert Jergens, DVM, PhD, DACVIM-SAIM, AGAF