Chronic inflammatory enteropathies (CIE) are a group of intestinal disorders characterized by persistent or recurrent gastrointestinal signs. Dogs with CIE often have frequent flare-ups and intestinal inflammation associated with changes in gut bacteria, and the cause of these flare-ups is rarely known. Researchers want to know if synbiotics (a mixture of probiotics and prebiotics) provide a health benefit to dogs with CIE. The team will study how synbiotics influence DNA methylation, a process by which genes promoting inflammation can be turned on and off. Findings from this study will provide a better understanding of how synbiotics work in the dog’s digestive system and if they can regulate gene expression to reduce gastrointestinal inflammation in dogs with CIE.
Grant amount awarded
Iowa State University Foundation
Albert Jergens, DVM, PhD, DACVIM-SAIM, AGAF