Immune-mediated hemolytic anemia (IMHA) is a deadly blood disorder that occurs when a dog’s immune system is triggered to attack its own red blood cells. Normal cells, including red blood cells, display “flags” to the immune system that they are normal body components and therefore should not be destroyed. Researchers will explore whether red blood cells from dogs with IMHA lack these flags, and whether red blood cell destruction increases when immune cells cannot recognize this flag. If successful, findings will significantly advance our understanding of IMHA, and could lead to new therapeutic approaches that specifically prevent red blood cell destruction in affected dogs.
Grant amount awarded
North Carolina State University
Erika Gruber-Hollingshead, DVM, DACVP