Mevalonate is a naturally occurring substance critical to many normal body processes, and recent studies show abnormally increased concentrations of mevalonate in the blood of cats with pancreas, liver and intestinal disorders. In human patients with increased blood mevalonate levels, immune cells produce abnormally high immune responses to bacteria. To find out if this also holds true for cats, researchers will measure concentrations of mevalonate, as well as certain molecules associated with inflammation, in the blood of cats diagnosed with intestinal, pancreatic and liver disorders, comparing their findings to healthy cats. If a link between mevalonate and digestive inflammatory diseases is found, this new information can be used to develop more effective diagnostic tools and treatments to help cats with inflammatory disorders.
Grant amount awarded
University of Illinois
David Williams, Vet MB, PhD
Gastroenterology (Liver, Stomach, Intestinal Tract)