Investigating Genetic Changes Associated with Feline Infectious Peritonitis (FIP)

Feline infectious peritonitis (FIP) is an incurable, fatal viral disease in cats caused by mutated feline enteric coronavirus. Although several FIP-related mutations have been identified, the role these mutations play in disease development is not well understood. Researchers will use full genome sequencing of viral strains derived from cats that naturally developed FIP, and genetic manipulation of the feline enteric coronavirus genome, to identify and study the impact of genetic changes in the viral genome on the behavior of the virus in its target cells – intestinal lining cells and white blood cells. Results will help identify major targets for FIP diagnosis and treatment to change the outcome for cats infected by this fatal virus.