Gallbladder mucocele formation has become one of the most common, poorly understood and deadliest biliary conditions in dogs. Gallbladder mucoceles develop when the gallbladder secretes abnormal amounts of mucus that eventually obstructs or ruptures the gallbladder. Researchers will identify biological and genetic mechanisms responsible for mucocele formation. This new information will help the team identify drugs to block processes responsible for the mucus mass formation as well as work toward developing a genetic test for assessing disease risk in individual dogs. Currently, veterinarians don't know why dogs develop mucoceles nor how to predict, prevent or reverse their development. Discovery of new diagnostics and treatments will help veterinarians manage this serious, emerging disease in their canine patients.
Grant amount awarded
North Carolina State University
Jody L. Gookin, DVM, Ph.D.
Gastroenterology (Liver, Stomach, Intestinal Tract)