Finding Ways to Block Hemangiosarcoma Tumor Growth

Hemangiosarcoma is an aggressive disease that is rapidly fatal in dogs. Studies suggest that hemangiosarcomas rely on cholesterol and lipids to fuel tumor growth. Researchers will further investigate how cholesterol and lipids promote cancer growth, and delve deeper into understanding the cell signaling pathways activated by these metabolites. The team also will use existing drugs to interrupt these processes to kill tumor cells. Findings will be used to optimize drug and chemotherapy combinations to provide better treatment options for patients. The development of new and less toxic approaches to treat canine hemangiosarcoma is an important step in improving survival rates for dogs diagnosed with this deadly cancer.