Finding New Treatment Targets for Canine Mammary Gland Cancer

Few targeted and effective chemotherapy options are available to treat mammary gland tumors in dogs. The Hippo signaling pathway regulates cell proliferation and death and, when dysregulated, is known to be involved in the development of breast cancer in women. Researchers will study this pathway in canine mammary gland cancer and correlate its presence with tumor type and grade. Researchers also will investigate a new chemotherapy drug that targets this pathway as a potential new treatment option and adjunctive therapy for dogs with mammary cancer not completely controlled by surgical excision.