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Hemangiosarcoma is a common and aggressive cancer in dogs that is fatal, despite treatment. Researchers previously discovered that drugs commonly used to treat heart disease are effective against hemangiosarcoma cells. It is believed these medications, called adrenergic receptor antagonists, inhibit metabolic pathways critical to tumor cell viability and growth. In this study, the team will examine how these drugs disrupt signaling pathways essential for hemangiosarcoma formation and growth. Subsequent studies will combine these drugs with standard chemotherapies for a reformulated treatment approach to help reduce chemotherapy-associated side effects and improve outcomes for dogs with hemangiosarcoma.

Study ID
D18CA-409
Study Status
Active
Start Date
02/01/2018
Grant amount awarded
$100,000
Grant recipient
University of Minnesota
Study country
United States
Investigator
Korpela, Derek M, DVM
Study category
Cancer