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Fewer than 50 percent of dogs with osteosarcoma live longer than one year after amputation and chemotherapy, and no significant advances in treatment or survival rates have occurred in the past 20 years. Researchers will evaluate how overexpression of a small microRNA (miR-9) influences the development of canine osteosarcoma, particularly how miR9 helps osteosarcoma cells spread. This project will characterize a key factor associated with osteosarcoma's aggressive behavior in dogs, thereby providing a critical platform for the development of more effective therapies that block the effects of miR9. The ultimate goal of this work is to improve the survival of dogs affected by this cancer.

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The Ohio State University
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United States
Cheryl A. London, DVM, PhD
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