Curbing Tumor Growth and Chemotherapy Resistance in Canine Hemangiosarcoma

Hemangiosarcoma is an aggressive and almost uniformly fatal cancer of dogs.
Researchers uncovered evidence that a common cellular signaling pathway is associated with
aggressive hemangiosarcoma tumor growth and chemotherapy resistance. Signaling pathways
are coordinated chemical activities in a cell that collectively control one or more cell functions.
Abnormal activation of signals often trigger or facilitate the development of diseases, including
cancer. Researchers will investigate how signaling pathways contribute to hemangiosarcoma
growth, and if existing drugs can interrupt the process to reduce tumor growth and chemotherapy resistance. Finding a new approach to treat canine hemangiosarcoma is a vital step in improving survival rates in dogs with this aggressive cancer.