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Researchers will use systems biology, a comprehensive way of looking at multiple factors involved in complex diseases, to study equine metabolic syndrome, a metabolic and hormonal disorder and the most common cause of laminitis in horses.

Researchers will identify potential disease-causing genetic mutations associated with equine pituitary pars intermedia dysfunction, also known as equine Cushing’s disease, a condition that can cause endocrine disease in horses, ponies and donkeys.

Researchers will investigate how the immune system impacts the development of the pituitary pars intermedia dysfunction and determine if antioxidant treatments might slow or prevent this hormonal disorder in horses and ponies.

Researchers will evaluate several drugs in a novel three-dimensional culture model to gauge their potential as new treatments for pituitary-dependent hyperadrenocorticism, also known as Cushing’s disease.

Researchers will study how diet composition affects insulin levels in horses with equine metabolic syndrome as a step toward improving dietary recommendations to control this condition.

Researchers will investigate diet-associated factors linked to the development of insulin dysregulation in horses.

Researchers will investigate the effect of a widely used anti-inflammatory drug in horses on equine metabolic syndrome, a hormonal disorder associated with laminitis.