Clinical Trials

Morris Animal Foundation funds many ongoing clinical trials essential to advancing veterinary medicine and improving the health of animals today and tomorrow. These studies help veterinarians develop and improve new diagnostics, treatments and preventives for pet illnesses, as well as improve the quality of care patients receive.


The information below will help you determine if your pet may qualify to enroll in a study. For complete information on each clinical trial, contact the veterinary teaching hospital conducting the study or consult your veterinarian.


Urothelial Carcinoma

North Carolina State University (D19CA-032)
Investigate the validity of a novel diagnostic test for the early detection of urothelial carcinoma, also known as transitional cell carcinoma (UC/TCC), the most common urinary tract cancer in dogs.
Inclusion Criteria: One of six breeds (Scottish terrier, beagle, West Highland white terrier, Shetland sheepdog, American Eskimo dog, Russell/Parson Russell terrier) at high risk of developing a UC/TCC, or a mix related to these breeds.
Enrollment Site: Dogs in the United States. Urine sample collection kit available from North Carolina State University

Urinary Tract Infections

Tufts University (D21CA-083)
Evaluate if three days of the antibiotic amoxicillin is as effective as seven days for the treatment of urinary tract infections in dogs.
Inclusion Criteria: Female and castrated male dogs, 1 to 11 years old, weighing 3-40 kg with urinary tract infections.
Enrollment Sites: Three Massachusetts clinics: Tufts at Tech, Worcester, MA; Tufts VETS, Walpole, MA; and Weston Veterinary Clinic, Weston, MA

Heart Failure Drug

University of California, Davis (D20CA-822)
Evaluate the safety and efficacy of the drug clevidipine in dogs with congestive heart failure associated with mitral valve disease. This is a small, preliminary, phase one clinical trial.
Inclusion Criteria: Dogs with myxomatous mitral valve disease and congestive heart failure (fluid present in the lungs).
Enrollment Site: University of California, Davis

Urinary Tract Infections

University of California, Davis (D20CA-044)
Evaluate a novel biotherapeutic for treatment of recurrent and multi-drug resistant urinary tract infections as an alternative to antibiotic treatment.
Inclusion Criteria: Dogs over 3 months old with more than one UTI within the past 12 months or dogs that had a multi-drug resistant bacterial strain identified in the urine.
Enrollment Sites: University of California, Davis Medical Teaching Hospital and Koret School of Veterinary Medicine, Israel

Immune-Mediated Hemolytic Anemia (IMHA)

Cornell University (Study ID: D19CA-067)
Evaluate the efficacy of a promising, novel treatment for severe blood disorder in dogs.
Inclusion criteria: Dogs diagnosed with intravascular IMHA
Enrollment sites: Cornell University and Cornell University Veterinary Specialists

Weight Management

University of Cambridge, United Kingdom (D22CA-406)
Identify how genetic risk factors and owner behaviors contribute to pet obesity. This study will fill knowledge gaps to improve prevention and treatment of obesity.
Inclusion Criteria: Labrador retrievers
Enrollment Site: Veterinary Hospital of the University of Cambridge


Anti-Clotting Drugs and Heart Disease

The University of Georgia (Study ID: D16FE-015)
Compare the efficacy of two drugs for preventing recurrent thromboembolism (blood clots) in cats that have experienced and recovered from a prior clot event due to heart disease.
Inclusion criteria: Client-owned cats that have been diagnosed with a thromboembolism due to cardiac disease.
Enrollment sites: Any veterinarian can enroll a cat, but examination by a board-certified veterinary cardiologist is required for inclusion in the study.

Clots & Heart Disease

University of California, Davis (D21FE-303)
Investigate the underlying reason why clots form in cats with hypertrophic cardiomyopathy, the most common feline heart disease.
Inclusion Criteria: Healthy cats previously diagnosed with hypertrophic cardiomyopathy.
Enrollment Site: University of California, Davis Teaching Hospital

Fecal Microbial Transplant for Feline Weight Loss

The Ohio State University (D22FE-009)
Assess the efficacy of fecal microbiota transplantation as an adjunctive therapy for weight loss in obese cats.
Inclusion Criteria: Client-owned obese, but otherwise healthy cats
Enrollment Site: The Ohio State University

For More Clinical Trials

Visit the searchable clinical trials database at the AVMA Health Studies Database for a comprehensive list of pet clinical trials in the United States and Canada, including Morris Animal Foundation-funded clinical trials.

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