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MicroRNA Expression Profiling of Canine Osteosarcoma

Osteosarcoma, commonly known as bone cancer, is a significant cause of death in large and giant breed dogs. Because cancer is believed to be fundamentally a genetic disease, genomic approaches are needed to study canine bone cancer. Scientists have determined that microRNAs (miRNAs), small nonprotein-coding molecules, play an important role in a variety of human cancers. Using a custom microarray technology, which the investigators have developed in their laboratories, researchers will identify which miRNAs are expressed in osteosarcoma and which are associated with certain breeds and prognoses. By studying miRNA expression in osteosarcoma, the investigators hope to identify new molecular targets for therapy that will lead to better treatment of this disease.

Dr. W.C. Kisseberth, The Ohio State University

Fully Sponsored: Doreen Jakubcak & Michael Malchow; Portuguese Water Dog Foundation; GREYlong