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Measuring chemotherapy drug resistance in dogs with T-cell lymphoma

Since the use of combination chemotherapy was first reported in 1968, little progress has been made in improving the survival of dogs with T-cell lymphoma. Effectively monitoring chemosensitivity – the number of tumor cells killed by chemotherapy– of individual lymphoma cells exposed to multiple agents over many treatments remains a challenge. Following the small numbers of cells that evade chemotherapy would provide information on the effectiveness of a particular chemotherapy agent. In this clinical trial, researchers will use state-of-the-art DNA technology to measure changes in this small population of resistant cancerous T-cells in client-owned dogs with lymphoma. Data will be used to personalize treatment protocols for individual dogs in hope of improving survival and quality of life.

Principal Investigator: Paul R. Hess, DVM, PhD, North Carolina State University

Sponsors: Portuguese Water Dog Foundation, Inc., CTW Foundation, Blue Buffalo Foundation, Petco Foundation, Flat-coated Retriever Foundation 

Study ID: D16CA-056