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Identifying Genetic Factors of Bone Cancer

Bone cancer, or osteosarcoma, is a relatively common disease in large and giant breed dogs and a leading cause of death in some breeds, such as greyhounds and rottweilers. MicroRNAs (miRNAs) are small nonprotein-coding RNAs involved in the initiation and progression of cancer in humans. Researchers will use a new genetic tool developed to determine which miRNAs are expressed in canine osteosarcoma cell lines and tumors. They will also try to identify the miRNAs associated with specific breeds, those associated with an individual dog’s prognosis and survival, and those identified as targets for developing new treatments for this painful disease.

Dr. Joelle M. Fenger, Ohio State University

Co-sponsor: Anonymous: for Tycho; Deborah J. Davenport, DVM, MS, DACVIM and Martin Drey, DVM, Borzoi Club of America