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Evaluating the Use of Stem Cells to Control Kidney Disease

Chronic kidney disease (CKD) is a common cause of illness and death in cats, yet most commonly used diagnostic tests cannot reliably detect the disease until the advanced stages. This late diagnosis makes treatment challenging at best. Scientists have been testing mesenchymal stem-cell therapy in rodents with renal disease, and the treatments show promise for reversing or stabilizing kidney function. Mesenchymal stem cells can differentiate into a variety of cell types, and intravenous administration of these cells has been proven safe for cats. this study will evaluate the therapy’s effectiveness in treating cats with CKD. If this study generates positive data, the results will significantly improve the development of new strategies to manage feline CKD using mesenchymal stem-cell therapy.

Dr. Steven Dow, Colorado State University

Co-sponsor: Douglas and Kathryn Miller, in memory of Marla & Priss; The Peter and Karen Iacovelli Charitable Foundation, Inc.; Pamela Winter, in memory of Karen Williams; Carolyn S. Norgren