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Scientists Evaluate Proteins with Potential to Detect Kidney Disease Earlier in Dogs

Chronic kidney disease (CKD) is a common cause of illness and death in dogs, yet most commonly used diagnostic tests are reliable only in the advanced stages of the disease. For example, an increase in the concentration of creatinine in the blood is the most commonly used biomarker for declining kidney function, but creatinine levels typically do not increase until relatively late in the disease progress. With Morris Animal Foundation funding, researchers at Texas A&M University investigated whether certain proteins found in the urine can serve as biomarkers to signal the early onset of progressive CKD. For one component of the study, they used proteomic techniques to identify different amounts of proteins and protein fragments in the urine of dogs with subclinical disease (before an increase in serum creatinine was observed) compared with dogs with early clinical disease (when creatinine is mildly elevated). Some of these proteins are known markers of kidney disease whereas others have the potential to serve as new biomarkers. This study also provided researchers with a unique opportunity to evaluate urinary proteins over the entire course of CKD in a single patient, which has led to a better understanding of how certain urinary proteins behave during the progression of CKD in dogs. The findings from this study will help to determine which urinary proteins are most promising for early detection and for monitoring the progression of CKD in dogs. (D07CA-311)


Posted by MAFon March 22, 2011.

Categories: Animal health, Canine health, Dog health


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Submitted by Pat Iglehart at: March 27, 2012
I just lost my little Maltese, Annie to CKD. I wish there had been proper testing to help with this disease.