Identifying Factors that Contribute to E. Coli Infections
MAF Successful Outcome: Increasing resistance to antimicrobial drugs, such as antibiotics, antivirals and antifungals, is becoming a challenge for the veterinary profession and could limit future treatment options for dogs and cats. Unfortunately, this trend is not nationally monitored. Researchers at Auburn University investigated drug resistance in Escherichia coli, a common infectious organism found in dogs and cats. E. coli infection is hard to treat effectively because it is resistant to many drug therapies.
The researchers evaluated E. coli samples collected from dogs and cats to document patterns of prevalence and antimicrobial resistance and susceptibility and to determine which drugs are ineffective. They tested 1,260 E. coli isolates (independently derived samples) and investigated the molecular mechanisms by which multidrug resistance is emerging in E coli. These isolates will provide a basis for studies regarding the rapid detection of m ultidrug resistance and will be used to assess novel drugs that could be therapeutically beneficial. Initial tests revealed that the percent of isolates resistant to routinely prescribed drugs ranges from a low of none to a high of 62.5 percent, depending on the drug used. Researchers also surveyed 230 veterinarians to collect clinical information on patients with E. coli infections, including pertinent history of the infection, antimicrobial use (drug dose and duration) and prescribing behaviors. These data will be used to identify demographics and risk factors of emerging drug resistance. The analyses and conclusions based on this massive collection of data should be available in early 2011 and will improve guidelines for treating E. coli infection. The project will also serve as a model for studying drug resistance in other infectious organisms. (D07MS-006)
Posted by MAFon June 21, 2010. Permalink