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Improving Ability to Predict Cancer Spread

Morris Animal Foundation–Funded Clinical Trial

D09CA-031, North Carolina State University, Dr. Marlene L. Hauck

Samples Requested: Canine soft-tissue sarcomas (including fibrosarcomas, hemangiopericytomas, peripheral nerve sheath tumors, liposarcomas, leiomyosarcomas, rhabdomyosarcomas and undifferentiated sarcomas)

Study Outline: Soft-tissue sarcomas are the most common type of solid tumors in dogs. They are locally invasive tumors with a high local recurrence rate. The metastasis rate varies from 5 to 40 percent depending on the tumor type and grade. The laboratory of Dr. Marlene Hauck is evaluating the genetic changes that are seen in soft-tissue sarcomas that metastasize versus those that do not. The goal is to identify a gene or protein expression "signature" that will more accurately predict which dogs will go on to develop metastasis in order to improve the outcome for dogs with soft-tissue sarcomas.

Sample Submission: Researchers are interested in receiving biopsy samples of dogs with soft-tissue sarcoma. It is recommended that the referring or primary veterinarian submit the sample. Researchers welcome any questions referring veterinarians or owners may have.

Sample Collection and Shipping: For each sample submission, the following is required:

Representative non-necrotic pieces of the tumor (preferably at least 1 cm3 or equivalent) collected as aseptically as possible in each of the following:

1. RNA stabilization solution (which researchers will provide)

It is very important that samples are placed in this solution immediately after biopsy.

2. Formalin

Basic patient information, clinical history and associated pathology reports relating to this tumor

Please contact the Hauck Lab at North Carolina State College of Veterinary Medicine in advance of sample collection, so that we may provide detailed collection instructions and arrange shipment of RNA stabilization solution and tumor samples.

Contact Details for Dr. Marlene Hauck's Lab:

Julie Fisher, Research Specialist
Room 326, CVM Research Building
Department of Clinical Sciences
College of Veterinary Medicine
North Carolina State University
4700 Hillsborough Street
Raleigh, NC 27606
Phone: 919.513.8276 Fax: 919.513.7301
E-mail: julie_fisher@ncsu.edu