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Comparing Drugs That Prevent Blood Clots

Morris Animal Foundation–Funded Clinical Trial

D09FE-001, Purdue University, Dr. Daniel Hogan

Location: Anywhere. Cats in the study are managed by their current veterinarian.

Patients needed: Cats, of any age and sex that have had a clinically evident cardiogenic embolic event no sooner than 1 month and no longer than 3 months previously. More details online at

Procedures performed: Physical exams and laboratory tests (complete blood count, chemistry panel). Appropriate concurrent cardiac therapy. Cats are randomly assigned to receive aspirin or clopidogrel.

Incentive: Financial assistance is available.

Study Outline: Cats with heart disease often develop painful blood clots. These pets frequently die from the clot or are euthanized due to quality-of-life concerns. Those that survive an initial event frequently suffer a subsequent clotting episode. Aspirin was the first drug used to prevent clot recurrence in cats, but there is no scientifically sound research to prove its effectiveness. Recently, veterinarians began using clopidogrel, which is successful in humans but hasn’t been tested in veterinary clinical trials. With previous MAF funding, the researchers began a clinical trial to compare the effectiveness of these drugs in preventing feline blood clots. Funding for this study will enroll an additional 70 cats into the clinical trial and provide the clinical information needed to determine which drug works best.

Daniel Hogan, DVM
Purdue University
School of Veterinary Medicine
Phone: (765) 496-6743