Researchers will study the genetic basis of subvalvular aortic stenosis in Newfoundland dogs, a high-risk breed for developing this devastating heart condition.
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Researchers will evaluate if the drug rapamycin can reverse the negative heart changes associated with subvalvular aortic stenosis, the most common congenital heart defect in dogs.
Researchers will use novel gene-editing tools to correct damaging mutations in heart cells to help advance gene therapies for dilated cardiomyopathy, a common canine heart disease.
Researchers will evaluate the safety and efficacy of the drug clevidipine in dogs with congestive heart failure associated with mitral valve disease.
Researchers will develop innovative tools to study dilated cardiomyopathy, a common cause of heart failure, in Doberman pinschers, a high at-risk breed.
Researchers will look at how lesions or nodules form in dogs with mitral valve disease and use this new information to look for new targeted therapies for this common canine heart disease.
Researchers will search for genetic mutations associated with mitral valve disease, a common heart condition in small breed dogs, to improve disease management and prevention.