Researchers will evaluate the potential of a novel drug derived from the feverfew plant to treat rapidly fatal canine cancers.

Researchers will study the cellular landscape of soft-tissue sarcomas in dogs to identify novel therapy targets.    

SUMMARY: Researchers will evaluate an innovative approach using engineered intracellular bacteria called quasiorganelles as a platform for the intracellular delivery of proteins to histiocytic sarcoma cells and surrounding immune cells in the local tumor environment. This proteins have been selected to suppress cancer growth and stimulate the immune system for the purpose of eliminating cancer cells.

Researchers will investigate the role of a genetic mutation found in about one third of dogs diagnosed with hemangiosarcoma, in an effort to find new therapies for dogs affected by this aggressive and highly metastatic cancer.

Researchers will use state-of-the-art gene editing techniques to identify genes that influence growth and progression of oral squamous cell carcinoma tumors in cats.

Cancer researchers have been improving treatments for different cancers by identifying genetic variants (errors in the genetic code) in the tumors, and by identifying or developing new drugs that can...

Researchers are exploring if a protein found in some human cancers is also present in hemangiosarcoma tumors, and is a feasible therapy target.

Researchers will use a technique called single-cell RNA sequencing to identify surface markers specific to canine hemangiosarcoma cells as a first step toward the development of a more effective and precise therapy.