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Understanding Two Common Causes of Tying-Up in Horses

Equine exertional rhabdomyolysis, a common syndrome in horses, involves episodes of muscle stiffness, sweating and tachycardia, and occasionally, severe and widespread muscle cell death, recumbency and death. Two genetic forms, recurrent exertional rhabdomyolysis and polysaccharide storage myopathy, are common causes of tying-up in horses, but in both diseases, the underlying mechanisms that lead to the clinical signs are poorly understood. Using cultured cells, researchers will evaluate pathways that generate and control energy production and determine whether they are defective in each of the disorders. This work will improve understanding of each of these diseases and, in so doing, may identify new ways to treat these debilitating disorders of horses. 

Principal Investigator: Dr. Charlotte J. Maile, Royal Veterinary College, Fellowship Training Grant

Sponsor: 

Study ID: D14EQ-404