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Understanding the role of abnormal calcium regulation in equine muscle diseases

Summary: Researchers will investigate how equine muscle cells regulate calcium movement, and examine its role in equine muscle diseases. 

Description: Shuttling calcium between cellular compartments is critical to normal muscle function. Abnormal movement of calcium can contribute to muscle degeneration and even failure. Researchers will explore biological mechanisms involved in equine muscle calcium regulation and “tying up,” a complex muscle disorder of horses. Researchers also will study how key equine inhibitory proteins affect the structural dynamics of the muscle calcium pump which helps control intramuscular calcium levels in the body. By discovering how horses regulate muscle calcium levels, researchers hope to identify new therapeutic targets for treating debilitating equine muscle diseases.


INVESTIGATOR: Dr. Stephanie J. Valberg, Michigan State University

SPONSOR(S): United States Eventing Association