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Understanding the Genetic Role miRNAs Play in Cancer

Cancer is a leading cause of death in cats. Understanding the genetic basis of cancer is crucial for improving diagnosis, treatment and prevention. Small non–protein-coding RNAs, called microRNAs (miRNAs), have recently been implicated as having a major role in gene regulation and cancer development (as well as development of many other diseases) in humans. These miRNAs have widespread effects on gene regulation and expression and have been shown to have great potential for treatment and diagnosis. Researchers will identify feline miRNAs using genome-wide computational analyses and will sequence the expressed miRNAs using next-generation (deep) DNA-sequencing technology. This study will help improve understanding of the role miRNAs  play in cat health.

Dr. Thomas J. Rosol, Ohio State University