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Exploring the Role of a Regulatory Protein in Canine Osteosarcoma

Osteosarcoma is the most common cancerous bone tumor in dogs, and it is most often diagnosed in large breed dogs. It is extremely aggressive and often fatal because of its ability to spread to the lungs and other organs. Despite advances in canine oncology, the prognosis for dogs with osteosarcoma has not changed in more than 20 years.  A small subset of cells within the tumor, called tumor-initiating cells, is thought to help osteosarcoma spread and resist chemotherapy. Researchers will explore the role of Frizzled-6, a protein that has been implicated in the regulation of tumor-initiating cells. A better understanding of Frizzled-6 will help researchers develop therapies that may improve outcomes for dogs diagnosed with osteosarcoma. 

Principal Investigator: Dr. Timothy J. Stein, - University of Wisconsin–Madison

Sponsors: 

Study ID: D15CA-059