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Understanding the Role of Specific Cells in Lymphoma Spread

Canine lymphoma accounts for up to 24 percent of all canine tumors, and more than 80 percent of hematopoietic cell cancers. Diffuse large B-cell lymphoma is the most common type of lymphoma in dogs. Despite efforts to establish effective chemotherapy protocols, long-term remissions are rare, and the median survival time for dogs with high-grade tumors ranges from 6 to 11 months. New strategies are required to improve survival and attain cures. One of the limitations in identifying therapeutic targets for canine lymphoma has been the lack of reliable systems to maintain and expand lymphoma cells in the laboratory. Previously, the researcher created a culture system to maintain lymphoma cells in the laboratory. In this study, he will use this system to stimulate CD40, a protein found in B lymphocyte cells that help lymphoma cells spread, and learn more about its signaling pathway. The findings may highlight novel targets for developing therapies to treat diffuse large B-cell lymphoma in dogs.

Dr. Daisuke Ito, University of Minnesota, First Award Grant

Co-sponsors: The American German Shepherd Dog Charitable Foundation, Inc.; Golden Retriever Foundation