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Improving the Feline Genome Assembly

Recently, domestic cat genome maps and sequencing resources have been effectively used to map and identify more than a dozen genes that influence feline disease and coat color. Many of these studies have led to genetic tests, but large fractions of the genome are misassembled and disagree with previous maps. Resolving the location and structure of duplications is critical, as a growing body of literature suggests that these structurally unstable regions hold information about a large number of diseases. Researchers will work to improve the feline genome sequence assembly using approaches made possible with recent technologies. A new ultra- high-resolution radiation hybrid map will be created using a new-generation sequencing-based genotyping method that has the potential to map millions of sequences across the genome. The results of this study will significantly improve the quality of the feline genome assembly and enhance the tools scientists use to study genetic diseases in cats.

Dr. William J. Murphy, Texas A&M University