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Improving Ability to Predict Cancer Spread

Soft-tissue sarcomas are common in dogs. While many are easily treated with local therapy, the disease spreads (metastasizes) and kills about one-third of affected dogs. Veterinarians can’t reliably predict which dogs will develop metastasis, making it difficult for them to determine which dogs should receive chemotherapy and whether treatment is working. Researchers will compare gene and protein expression patterns of tumors that spread to those that don’t and will use the information to develop a more reliable test for predicting metastasis. If successful, this test will help veterinarians improve canine cancer treatment and will also improve the overall understanding of this disease so that scientists can further study potential intervention therapies.