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Identifying Molecular Markers of Virulent Feline Calicivirus Infection

Feline calicivirus (FCV), a common viral disease that affects cats, causes upper respiratory symptoms, pneumonia and mouth sores. Despite increased vaccination rates, FCV remains a highly prevalent feline pathogen that causes significant morbidity and occasional death. the available vaccines protect against disease but not infection, and the most devastating type of the disease can still appear in cat populations. researchers will examine the interaction between FCV and a cell surface receptor called feline junctional adhesion molecule A (fJAM-A). They suspect that newer, more virulent isolates of FCV undergo dramatic changes when they interact with fJAM-A and that these changes make the strains more efficient at infecting cats. the information from this study could help identify the virulent virus early so cats can be treated quickly.

D12FE-002
Dr. John S. Parker, Cornell University