Determining Factors That Cause Chemotherapy Resistance
Canine histiocytic sarcoma is an aggressive form of cancer that is almost always fatal. The disease affects primarily Bernese mountain dogs, flat-coated retrievers and rottweilers, but others are predisposed as well. Despite rigorous efforts to identify genetic abnormalities underlying this disease, few treatment advances have been made. The researchers will focus on gene expression patterns that are associated with this cancer's resistance to chemotherapy. They intend to develop a practical test that can be used to guide future drug development for the treatment of canine histiocytic sarcoma.