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Evaluating a Drug’s Effectiveness in Reducing Inflammation after Colic Surgery

Inflammation develops in all layers of the small and large intestines of horses after colic surgery, causing postoperative complications and even death. This study examines the ability of lidocaine, a local anesthetic, to reduce inflammation in the horse’s intestine when delivered by continuous intravenous infusion. A favorable response would support continued use of lidocaine, whereas failure to reduce inflammation would prompt the search for a more effective drug.

Dr. Astrid Grosche, University of Florida