D05CA-606: Genes and Canine Hip Dysplasia

principal investigator: Steven Friedenberg, student, Cornell University

Project Mentor: Rory Todhunter, BVSc, PhD

completed

Year: 1 of 1. $0

Canine hip dysplasia (CHD) is the most common inherited orthopedic disease in dogs, leads to osteoarthritis and pain, and remains prevalent in dogs despite attempts to exclude affected dogs from breeding. One reason it is difficult to eradicate is because it is a "complex" trait which means more than one gene contributes to its development. Through this research two potentially significant genes that may play a role in development of this disease were identified. These genes were then sequenced using DNA of both affected and unaffected dogs to search for genetic mutations. While no mutations have been found yet, a marker of interest in a gene called fibrillin 2 was identified. Further studies are underway to confirm this marker in a larger group of dogs, which could then potentially be used as a genetic test for CHD.

Steven says, "I have always been interested in scientific research and having the opportunity to work with Dr. Todhunter this summer solidified my interest in this area. Furthermore, working with Dr. Todhunter stimulated my interest specifically in studying the genetic basis of orthopedic disease. (This topic) I hope to continue studying in my career as an academic veterinarian."