research studies » current studies
In 2008, Morris Animal Foundation will fund nearly 200 new and continuing studies for dogs, cats, horses, llamas/alpacas, and wildlife as well as more than 40 veterinary student projects.
We also have numerous studies nearing completion. You can search our current study database by species and/or disease to learn more about the studies we are funding in the areas you care most about. The results will also show you whether a study is available for sponsorship.
Category
D06CA-063: Pilot Study: Biopotency of Trilostane and Ketotrilostane in Adrenal Slices
principal investigator: Ellen N. Behrend, VMD, PhD, Auburn University
Nearly Complete
sponsorship not needed
Year: 0 of 0. $0
Hyperadrenocorticism (HAC), also known as Cushing's disease, is one of the most common endocrine diseases of older dogs. It occurs when the adrenal gland secretes too much cortisol, causing excessive eating, drinking and urinating; lethargy; abdominal enlargement; panting; obesity; muscle weakness and recurrent urinary infections. Mitotane, the primary treatment, has many adverse side effects. Another drug, trilostane, is used extensively in Europe to treat HAC in dogs, but very little is known about its efficacy and safety. Researchers will study the potency of trilostane and one of its metabolites, ketotrilostane. What they learn will provide the basis for future studies into determining the safest and most effective dose of trilostane. This drug also has the potential for treating other non-adrenal diseases.
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