Morris Animal Foundation

Along the way, our studies have led to major advances in veterinary care, including vaccines and other preventions, diagnostic tools and new therapies for the diseases and health conditions that threaten the lives of the animals we love. You can search our completed-study database by species and/or disease to learn more about our successes.

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D05CA-606: “Genes and Canine Hip Dysplasia”

principal investigator: Steven Friedenberg, student, Cornell University
completed
Project Mentor: Rory Todhunter, BVSc, PhD

Canine hip dysplasia (CHD) is the most common inherited orthopedic disease in dogs, leads to osteoarthritis and pain, and remains prevalent in dogs despite attempts to exclude affected dogs from breeding. One reason it is difficult to eradicate is because it is a “complex” trait which means more than one gene contributes to its development. Through this research two potentially significant genes that may play a role in development of this disease were identified. These genes were then sequenced using DNA of both affected and unaffected dogs to search for genetic mutations. While no mutations have been found yet, a marker of interest in a gene called fibrillin 2 was identified. Further studies are underway to confirm this marker in a larger group of dogs, which could then potentially be used as a genetic test for CHD.

Steven says, “I have always been interested in scientific research and having the opportunity to work with Dr. Todhunter this summer solidified my interest in this area. Furthermore, working with Dr. Todhunter stimulated my interest specifically in studying the genetic basis of orthopedic disease. (This topic) I hope to continue studying in my career as an academic veterinarian.”