Potential prognostic lymphoma test
Dr. Matthew Breen
North Carolina State University
Dr. Sue Lana
Colorado State University
Lymphoma accounts for nearly 25 percent of all cancers in dogs, and some breeds are particularly susceptible. Untreated dogs rarely survive beyond three months after diagnosis. Even with chemotherapy, overall response and survival times vary widely, indicating a need to develop more refined modes of classification.
Studies have shown that certain chromosome changes in humans with lymphoma have both diagnostic and prognostic significance. Investigators from North Carolina State University and Colorado State University have also identified recurrent chromosome changes in canine lymphoma that show prognostic significance for dogs with this cancer. They identified a key genetic signature of canine lymphoma that correlates with disease-free intervals in dogs treated with chemotherapy. This information will provide the basis for scientists to develop a valid prognostic test for dogs with lymphoma that would help owners and veterinarians make more informed decisions about treatment.
Posted by MAFon December 14, 2011. Permalink