Insight Into Chemotherapy Resistance
Cancer is the leading cause of disease-related death in dogs, which is why Morris Animal Foundation has invested considerable resources into understanding this group of diseases and developing more effective treatments. Cancer develops when genes that control the balance of cell division and survival cease to function normally and cause a cell to become malignant. One of these genes is called PTEN. The protein product of this gene generally restrains cell division, in part by controlling p21, another protein. Scientists at the University of Minnesota and the University of California–Davis found that using compounds to lower the levels of p21 in some tumors decreased resistance to conventional chemotherapy drugs. They also concluded that chemotherapy resistance is sometimes unrelated to abnormalities of PTEN, though it is often associated with elevated p21 levels. The results from this MAF-funded project allowed the investigators to justify efforts to move these compounds to the next step of clinical development.
Posted by MAFon September 9, 2009. Permalink